With the rapid development of biopharmaceutical industry, the application of tangential flow filtration device in the separation and purification of biomolecules is increasing day by day.

As a key link in a tangential flow filtration system, flow measurement directly affects the separation efficiency of the system.

Compared with the traditional flow measurement equipment, the ultrasonic flow sensor, as a new type of flow measurement component, has the advantages of high precision, good stability, no pollution, etc., which makes it very suitable for tangential flow filtration systems.

What is tangential flow filtration

The tangential flow filtration is a separation technology in which the feed material passes through the filter in a direction basically parallel to the filter membrane, so that large molecules are retained while small molecules penetrate through the filter membrane.

The basic working principle of tangential flow filtration.

Step 1: The feed material is adjusted to a certain pressure by the pressure stabilizer and then enters the tangential flow filtration module.

Step 2: When the feed material flows through the filtration membrane, the large molecules are retained above the filtrate, while the small molecules flow out with the permeate through the permeate holes under the membrane.

Step 3: The concentrate left on top is returned to the feed end of the filtration system through the pipeline, realizing the internal circulation filtration and concentration.

Tangential flow filtration systems are widely used in various fields because of their efficiency. As the key component of tangential flow filtration system automation control, the correct selection of flow sensors is of great significance.

How to choose a proper flow sensor / flow meter?

1. Select the ultrasonic flow sensor with high measurement accuracy

The CG clamp on flow sensor/flow meter can measure real-time liquid flow rate, with the measurement accuracy up to ± 1%, which can perfectly meet the tangential flow filtration system flow monitoring needs of high accuracy.

2.Select the ultrasonic flow sensor with fast response speed

The CG clamp on flow sensor/flow meter enable monitor flow rate change in milliseconds. The CG clamp on flow sensor/flow meter  can reflect flow rat changes in the filtration system in real time, which is  the foundation of accurate bio flow control of the filtration process.

3.Select ultrasonic flow sensors with a wide measuring range

The CG clamp on flow sensor/flow meter has a wide range of flow rate measurement ranges to meet the needs of different types of tangential flow filtration systems.

4.Select ultrasonic flow sensors that are not affected by the fluid type

The CG clamp on flow sensor/flow meter use ultrasound waves for flow measurement, independent of the electrical properties of the fluid, viscosity, density, and other parameters, can be applied to various types of liquids, especially those containing proteins, cells, and other media of biological fluid filtration systems.

5.Select the Low Maintenance Flow Sensor / Flow Meter

The CG clamp on flow sensor/flow meter adopt clamp-on design, no internal moving parts, which can reduce flow rate measurement error, and lower the maintenance costs.

6.Select ultrasonic flow sensors / flow meters  that are easy to install and disassemble

The CG clamp on flow sensor/flow meter are designed to be clamped-on the flexible tubing and can be installed or disassembled without disrupting or stopping the production.

What is the role of ultrasonic flow sensors / flow meters in tangential flow filtration systems?

CG series ultrasonic flow sensors / flow meters are widely used in tangential flow filtration systems for bio flow rate measurement, fluid monitoring, early flow rate abnormal warning, filtration liquid optimization, and other functions.

1.Tangential Flow Measurement and Monitoring

In tangential flow filtration systems, accurate measurement and control of the tangential flow rate are essential to maintaining a stable permeate flux.

CG series ultrasonic flow sensors / flow meters are used to monitor the filtrate and feed flow rates in real time. Based on the flow rate feedback, the filtration system can accurately adjust the pump speed to accurately control the filtrate volume and ensure filtration efficiency.

2.Early Warning of Clogging of the Filter Membrane

CG series ultrasonic flow sensors / flow meters can monitor the filtrate flow changes so as to determine whether the membrane is clogging. Once an abnormal drop in flow rate is detected, the machine can be shut down in time to check and replace the membrane to avoid affecting the filtration effect and causing damage to the membrane and other piping components.

3.Filtrate Collection Control

Based on the real-time flow feedback from CG series ultrasonic flow sensors / flow meters, the amount of filtrate collected can be accurately controlled to avoid overflow or insufficiency.At the same time, users can also set a target filtrate volume and automatically stop the filtrate collection when the set value is reached.

4.Filtering, Process Monitoring, and Optimization

During the filtration process, the CG series ultrasonic flow sensors / flow meters can continuously monitor the volume of filtrate to determine whether the filtration process is normal. 

For more flow sensor / flow meter information, please visit the XYTEK website at https://xy-tek.com

Contact XY-TEK team at global@xy-tek.cn

XYTEK engineers would be delighted to arrange the flow sensor/flow meter demonstration or provide further information to help make the flow meter selection choice.

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