With the rapid development of biopharmaceutical industry, the application of tangential flow filtration system in the separation and purification of biomolecules is increasing day by day.

As a key link in a tangential flow filtration system, flow measurement directly affects the separation efficiency of the system.

Compared with the traditional flow measurement equipment, the ultrasonic flow sensor, as a new type of flow measurement component, has the advantages of high precision, good stability, no pollution, etc., which makes it very suitable for tangential flow filtration systems.

So, what is tangential flow filtration?

The tangential flow filtration is a separation technology in which the feed material passes through the filter in a direction basically parallel to the filter membrane, so that large molecules are retained while small molecules penetrate through the filter membrane.

The basic working principle of tangential flow filtration.

Step 1: The feed material is adjusted to a certain pressure by the pressure stabilizer and then enters the tangential flow filtration module.

Step 2: When the feed material flows through the filtration membrane, the large molecules are retained above the filtrate, while the small molecules flow out with the permeate through the permeate holes under the membrane.

Step 3: The concentrate left on top is returned to the feed end of the filtration system through the pipeline, realizing the internal circulation filtration and concentration.

Tangential flow filtration systems are widely used in various fields because of their efficiency. As the key component of tangential flow filtration system automation control, the correct selection of flow sensors is of great significance.

How to choose a proper flow sensor?

1. Select the ultrasonic flow sensor with high measurement accuracy

XY TEK Ultrasonic flow sensor can measure real-time liquid flow rate, with the measurement accuracy up to ± 1%, which can perfectly meet the tangential flow filtration system flow monitoring needs of high precision.

2.Select the ultrasonic flow sensor with fast response speed

XY-TEK Ultrasonic flow sensors enable millisecond monitoring of flow changes. This makes it possible to reflect flow changes in the filtration system in real time and is the basis for realizing precise control of the filtration process.

3.Select ultrasonic flow sensors with a wide measuring range

XY-TEK Ultrasonic flow sensors has a wide range of measurement ranges to meet the needs of different types of tangential flow filtration systems.

4.Select ultrasonic flow sensors that are not affected by the fluid type

XY-TEK ultrasonic flow sensors use sound waves for flow measurement, independent of the electrical properties of the fluid, viscosity, density, and other parameters, can be applied to various types of liquids, especially those containing proteins, cells, and other media of biological fluid filtration systems.

5.Select clamp-on non-invasive ultrasonic flow sensors and flow meters

XY-TEK ultrasonic flow sensors adopt clamp-on design, no internal moving parts, which can reduce the source of measurement error, and maintenance costs.

6.Select ultrasonic flow sensors that are easy to install and disassemble

XY-TEK Ultrasonic flow sensors are designed to be clamped-on the pipeline and can be installed or disassembled without disrupting or stopping theproduction.

What is the role of ultrasonic flow sensors in tangential flow filtration systems?

XY-TEK ultrasonic flow sensors are the accurate flow measurement devices widely used in tangential flow filtration systems for fluid measurement, fluid monitoring, early warning, filtration optimization, and other functions.

1.Flow Measurement and Monitoring

In tangential flow filtration systems, accurate measurement and control of the tangential flow rate are essential to maintaining a stable permeate flux.

XY-TEK ultrasonic flow sensor is used to monitor the filtrate and feed flow rates in real time. Based on the flow rate feedback, the filtration system can accurately adjust the pump speed to accurately control the filtrate volume and ensure filtration efficiency.

2.Early Warning of Clogging of the Filter Membrane

XY-TEK ultrasonic flow sensor can monitor the filtrate flow changes so as to determine whether the membrane is clogging. Once an abnormal drop in flow rate is detected, the machine can be shut down in time to check and replace the membrane to avoid affecting the filtration effect and causing damage to the membrane and other piping components.

3.Filtrate Collection Control

Based on the real-time flow feedback from the XY-TEK ultrasonic flow sensor, the amount of filtrate collected can be accurately controlled to avoid overflow or insufficiency.At the same time, users can also set a target filtrate volume and automatically stop the filtrate collection when the set value is reached.

4.Filtering, Process Monitoring, and Optimization

During the filtration process, XY-TEK ultrasonic flow sensor can continuously monitor the volume of filtrate to determine whether the filtration process is normal.