With the rapid development of biopharmaceutical technology, the demands for detecting and quantifying biologics are increasing.

Chromatographic filtration is a commonly used analytical method in biopharmaceuticals, where flow control plays a crucial role in achieving efficient analysis.

In recent years, clamp on ultrasonic flow sensors / flow meters have gradually become the vital component of chromatographic filtration devices, due to the advantages of high flow rate measurement accuracy, and no contamination flow rate measurement ability.

Chromatographic Filtration

Chromatographic filtration is an important separation and quantification technology in biopharmaceuticals, widely used in the purification, detection, and quantitative analysis of biomolecules process.

Chromatographic filtration refers to the separation and determination of multi-component mixtures by utilizing the differences in the physical and chemical properties of each component in the mixture.

The mechanism of chromatography can be divided into adsorption chromatography, distribution chromatography, ion exchange chromatography, gel filtration chromatography, and so on.

In the process of chromatography, controlling the flow rate significantly influences the efficiency of the chromatographic column, the separation effect of the samples, and the overall results of the experiment.

Traditional flow controllers, such as rotary pumps and piston pumps, have achieved some success in practical applications.

However, their complex structure and limited lifespan make it challenging to meet the demand for high-accurate and high-stability flow control in biopharmaceuticals process.

Therefore, the adoption of flow rate measurement technology has become an urgent need.

The Working Principle of Clamp-on Ultrasonic Flow Sensor / Flow Meter

Ultrasonic flow sensors /flow meters, has been gradually adopted in the biopharmaceutical chromatography filtration process.

The clamp on Ultrasonic flow sensors / flow meters  utilize ultrasonic propagation characteristics in the fluid medium to measure the bio liquid. Their working principle is based on the ultrasonic Transit-time difference technology.

When the ultrasonic wave propagates downstream, its propagation time decreases due to the fluid flow; conversely, in the upstream, its propagation time increases due to the fluid flow. Ultrasonic flow sensors or ultrasonic flow meters measure the ultrasonic propagation time in both downstream and upstream to calculate fluid flow rates and cumulative volume.

The main components of the clamp on ultrasonic flow sensor include the transmitter, receiver, signal processor, and optional display . The transmitter is responsible for generating ultrasonic signals, the receiver is responsible for receiving the ultrasonic signals during the propagation process, the signal processor processes and calculates the received signals, and finally, the display shows the measurement results.

This non-invasive flow sensor / flow meter not only reduces interference with the fluid but also achieves high flow rate measurement accuracy and stability.

XY-TEK Clamp-on Flow Sensor/Flow Meter

CG series Clamp on Flow Sensor / Flow Meter Introduction

The CG series clamp on flow sensor / flow meter has a high flow rate measurement accuracy of ±1%.

The clamp-on design enables the ultrasonic flow sensor / flow meter does not direct contact with the measured fluid. It can be easily installed and disassembled within a few steps

In addition, the clamp-on ultrasonic flow sensors / flow meters can be flexibly deployed near the inlet and outlet of critical tubing and pumps to monitor the aging of the tubing or the degradation of the pump performance.

This allows for early intervention to prevent unnecessary wastage of reagents and experimental failures.

CG series Clamp-on Ultrasonic Flow Sensor / Flow Meter

Advantages of XY-TEK Ultrasonic Flow Sensors / Flow meters in Biopharmaceuticals Chromatographic Filtration

Compared to traditional flow meters,  the CG clamp on flow sensors / flow meters offer the following advantages in the biopharmaceuticals chromatographic filtration.

1.High Accuracy

The CG clamp on flow sensors / flow meters offers an accuracy of up to ±1%, allowing precise control of the flow rate and improve the analysis result of chromatographic experiments.

2.High Stability

The CG clamp on flow sensors / flow meters features no moving parts, and reduces measurement errors caused by wear and tear of components.

3.Non-contact Flow Rate Measurement

The CG clamp on flow sensors / flow meters utilizes non-invasive measurement, not directly interference with the fluid, which effectively prevents the risk of the sample contamination and loss of biological activity.

4.Wide Flow Rate Measurement Range

The CG clamp on flow sensors / flow meters offers a broad measurement range, enabling accurate measurement of both low and high flow rates. It is suitable for various chromatography applications in biopharmaceuticals industry.

5.Easy to Maintain 

The CG clamp on flow sensors / flow meters have no wear and tear parts during use, and no need for regular part replacements, reducing maintenance costs.

XY-TEK CM series Ultrasonic Flow Sensor / Flow Meter

The CG clamp on flow sensors / flow meters use in Biopharmaceuticals Chromatographic Filtration

1.Protein Purification

High-Performance Liquid Chromatography (HPLC) is a commonly used method for separating and analyzing proteins during the purification process.

By using the CG clamp on flow sensors / flow meters, precise control of the mobile phase and the sample can be achieved, thereby enhancing the efficiency of protein separation.

In this process, the high accuracy and stability of  the CG clamp on flow sensors / flow meters, help enhance protein purity and yield while reducing the risk of protein inactivation.

2.Antibody-drug Analysis

Antibody drugs, as crucial products in the biopharmaceutical field, have stringent requirements for quality and purity. The CG clamp on flow sensors / flow meters, plays a crucial role in the high-performance liquid chromatography (HPLC) method for analyzing antibody drugs. By controlling the flow rate accurately, effective separation of antibody drugs can be achieved, thereby enhancing the quality and efficacy of the drugs.

3.Biopharmaceutical Production Process Monitoring and Control

In the biological drug production process, real-time monitoring of key parameters is essential.

For example, in the chromatographic online monitoring of the production process of biological drugs, the sample is separated by the chromatographic column. The components will flow out in a certain order. The CG clamp on flow sensors / flow meters,can monitor the flow rate of the components as they flow out..

Then, according to the detector to obtain the signal, combined with the retention time of the chromatographic column, the computer software processes the data in real-time to monitor the concentration of nutrients in the culture medium. This helps optimize the production process and improve the yield and quality of biopharmaceuticals.

The clamp on ultrasonic flow sensors / flow meters, play a significant role in the chromatographic filtration of biopharmaceuticals, offering notable advantages. This technology has emerged as a new focal point in biopharmaceutical applications.

With the continuous development of ultrasonic flow sensor/ flow meter technology, its application in the chromatographic filtration of biopharmaceuticals will become more extensive and in-depth.

Through continuous optimization of clamp on  flow sensor / flow meter performance and functionality, it is expected to provide more efficient, accurate, and reliable analysis methods for the biopharmaceutical industry, and to promote the ongoing development of biopharmaceutical technology.

Clamp-on Flow Sensor / Flow Meter

For more flow sensor / flow meter information, please visit the XYTEK website at https://xy-tek.com

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