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Cultivated Meat Production Bioprocess

Cultivated meat, also known as cell-based meat, lab-grown meat, or cultured meat, refers to meat products that are produced by cultivating animal cells in a controlled environment rather than by raising and slaughtering animals.

This innovative approach utilizes cellular agriculture technologies, aiming at a more sustainable, ethical, and potentially healthier alternative to conventional meat production.

Non-invasive flow measurement is crucial in ensuring effective, sustainable, and high-quality cultivated meat production. By enabling accurate flow media measurement and monitoring, the CG series ultrasonic flow sensor reduces risks of flow contamination and cell damage and contributes significantly to the overall efficiency and success of the cultivated meat production bioprocessing.

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Industry Challenges

Cell Density Variations

As cell cultures grow, their density can fluctuate, affecting the flow characteristics of the medium. This variability makes it challenging to obtain consistent and accurate flow rate measurements.

01
Shear Sensitivity

Cultivated meat cells can be sensitive to shear forces. Traditional flow measurement techniques may introduce shear stress that could negatively affect cell viability and growth, necessitating more delicate, non-invasive methods.

02
Sensor Fouling

Sensors, particularly invasive ones, can become fouled with biomass or nutrients over time, leading to decreased accuracy and reliability in flow rate measurement.

03
Bubble Formation

Gas bubbles can form in bioreactors, especially during aeration or cell respiration. These bubbles can interfere with flow measurements by disrupting the fluid flow and causing inaccuracies in the readings.

04
Scale-Up Challenges

As production scales from lab to pilot or industrial levels, maintaining accurate flow measurement becomes increasingly complex. Scale-up can change fluid dynamics, necessitating adjustments to measurement strategies and equipment.

05
Integration

Flow sensor/meter must integrate seamlessly with other bioprocessing controls (e.g., temperature, pH, and oxygen levels). Ensuring that all systems communicate effectively can be a challenge in maintaining overall bioprocessing efficiency.

06

Application Overview

During the cell culture phase, appropriate growth media must be supplied to the cultured cells. Monitoring the media flow rate is crucial to ensure that cells receive the necessary nutrients, factors, and oxygen needed for proliferation.

Perfusion Bioreactor
When fresh media continuously flows into the system while spent media is removed, flow measurement ensures that nutrients are delivered efficiently, and the waste products are effectively cleared.
Medium Recirculation and Mixing
Measuring the mixing of culture medium to ensure homogeneous nutrient distribution and prevent nutrient gradients that could inhibit cell growth.
Cell Harvesting
The flow rate of the cell suspension is measured to ensure the harvesting is efficient and that no cells are lost or damaged during the process.
Downstream Processing
In downstream processing (filtration centrifugation, etc.), CG ultrasonic flow sensor aids in the separation and purification of the cell product, ensuring the desired yield and quality of the final cultivated meat product.
Real-Time Monitoring
Combining the CG series flow sensor with process control systems can facilitate real-time monitoring automation, enhancing quality control throughout the production process.

Applicaiton Highlights

No Contamination

Whether users operate at a pilot scale or commercial scale, one single bacterium can jeopardize an entire batch. The CG series clamp-on ultrasonic flow sensor boasts a non-invasive design that avoids direct contact with the measured media, thereby preserving the integrity of the production process.
High Precision

The CG series delivers ±1% accuracy, crucial for maintaining precision in critical processes such as cultured media formulation.
Hassle-free Installation

The clamp-on design ensures easy installation on various bioreactor sizes without extensive modifications.
Compatibility

a) Accurately monitor flow variations to maintain consistent media flow rates throughout each step. b) Real-time flow data allows for prompt adjustments in operational parameters to respond to evolving flow requirements. c) Quickly identify faulty components when abnormal flow rates are detected, simplifying troubleshooting efforts.
Various Tubing Sizes

CG series sensors come in 12 sizes, accommodating tubing outer diameters (OD) ranging from 4mm to 30mm. It supports different bio-reactor sizes and tubing diameters, offering flexibility for various applications.