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Bioreactors

Bioreactors serve as controlled environments where biological reactions take place, playing a pivotal role in the production of pharmaceuticals, vaccines, and various bioproducts.

It utilizes microorganisms, cells, or enzymes to produce desired outcomes under optimal growth conditions such as temperature, pH, and nutrient supply. In the biopharmaceutical industry, bioreactors are essential for the controlled scaling of biological processes, ensuring consistent quality and safety in final products.

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Industry Challenges

Contamination Risk

Invasive bio-media flow rate measurements can introduce contaminants, affecting the quality of the final bio-products.

01
Operational Downtime

In-line flow sensors often require probe insertions that disrupt processes and necessitate maintenance, leading to costly downtime.

02
Inconsistent Measurements

Maintaining precise control over fluid dynamics is critical; discrepancies can compromise research outcomes and product integrity.

03
Flow Pressure

Excessive flow pressure can cause shear stress on microbial, which may decrease the yield of the desired bio-product.

04

Application Overview

In response to these challenges, the industry is increasingly turning to non-invasive flow rate measurement.The CG Series clamp-on ultrasonic flow sensors/flow meters is ideal for the bio-reactor flow rate measurement. It can provide accurate flow measurement, and ensuring the integrity and safety of bioprocessing.

Application Highlights

No Contamination

The clamp-on design of the CG series minimizes the risk of contamination during aseptic filling, enhancing product safety and quality.The non-invasive measurement reduces the risk of contaminating sensitive biological media. Unlike inline measurement sensors, which can introduce foreign substances or induce cell damage, CG series clamp-on ultrasonic flow sensors/flow meters maintain the purity of the bio-media, which is essential for generating reliable experimental data and high-quality bio-products.
Reduced Downtime

The CG Series clamp-on ultrasonic flow sensors/flow meters allows continuous flow measurement without complex installations or disrupting the maintenance procedures.
Consistent Flow Measurement Results

Flow measurement results consistency is crucial for ensuring that data is reliable for decision-making, conducting analyses, and validating processes, ultimately contributing to improved outcomes in biopharmaceutical production.
Wide Measurement Range

CG Series clamp-on ultrasonic flow sensors/flow meters are designed to accommodate a broad flow rate range making them suitable for applications ranging from low flow rates in cell cultures to high flow rates in large-scale fermentation processes.
High Accuracy ±3%

CG Series clamp-on ultrasonic flow sensors/flow meters effectively capture transient flow characteristics essential for dynamic biological processes. This capability ensures that any rapid changes in flow conditions are accurately monitored, facilitating better process control.

Advantages

Minimal Pressure Loss

The clamp-on design of the CG Series ultrasonic flow sensors prevents significant pressure loss in the system, which is crucial for maintaining optimal conditions within bioreactors, which can directly impact cell metabolism and product yields.
Versatility Across Bioreactor Configurations

CG series ultrasonic flow sensors/flow meters are adaptable to various bioreactor setups, including stirred tanks, bioreactors, and membrane bioreactors, allowing for tailored solutions that meet diverse bioprocessing requirements.
Low Maintenance

CG Series clamp-on ultrasonic flow sensors/flow meters typically demand less maintenance than traditional contact-based sensors, leading to lower labor costs and increased efficiency in bioprocessing environments.
Multi-Functional Capabilities

Support bubble detection and alerts, bi-directional flow measurement, and multiple output modes to integrate seamlessly with existing systems, offering enhanced functionality.